Detect High Numbers of Analytes with Specificity

Clinical biomarker services

Immunoassays are used to measure the presence and/or concentration of an analyte (protein, hormone, antibody). A main characteristic of immunoassays is their high specificity, resulting from the use of analyte specific antibodies. These can detect the analyte of interest at even low concentration.

Depending on the format, immunoassays use different detection signals to indicate the binding of the antibody to the analyte. The luminescence detected can be the result of an enzymatic reaction, an electrochemiluminescence (ECL) signal, or a fluorescent dye. Streamline data interpretation is achieved with automation and rapid measurement of detection signals.

As part of its full range of clinical biomarker services, Caprion offers three types of immunoassays which can all be tailored to your needs: ELISA, MSD®, Luminex®.

ELISA
(enzyme-linked immunosorbent assays)

ELISAs are well-established single-analyte assays that delivers robust and reliable data. With a high-throughput capacity, they provide quick and efficient monitoring of critical biomarkers.

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Meso Scale Discovery® (MSD) platform

MSD® is a highly sensitive and multiplexed platform for cytokine/chemokine screening. It allows the measurement of up to ten analytes in each well of a 96- or 384-well plate using serum or plasma samples as small as 25 μL. MSD® offers up to 40 plex format and can be customized for specific cytokines/chemokines of interest.

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Luminex®

Luminex® is a multiplex bead-based assay ideal for measuring the expression of multiple biomarkers in limited samples. The antibody-coated beads have unique fluorescent intensities, enabling the quantification of up to 30 analytes simultaneously in one sample.

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Related Services

Immunoassays are a component of Caprion’s full range of clinical biomarker services. They are often combined with cellular assays such as ELISpot/FluoroSpot or flow cytometry assays to generate a complete immune profiling.

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