Caprion

Accelerating precision medicine™

MRM Assays

MRM Assay Development for Rapid Validation of Protein Biomarkers

Caprion's platform and expertise go well beyond the biomarker discovery process. Caprion provides robust and quantitative mass spectometry based MRM (Multiple Reaction Monitoring) assays for rapid multiplexed verification and validation of biomarkers.

Multiplexed MRM assays offer a fast and cost-effective alternative to immunoassays for tracking panels of protein biomarkers selected from genomics, literature or discovery efforts. Multiplexed MRM assays for hundreds of candidate proteins can be developed in a matter of weeks (vs. years for multiplexed antibody ELISA).  MRM is the tool of choice to assess a large number of candidates, to derive a focused panel of relevant biomarkers, prime for further development using quantitative MRM or antibody-based approaches.

MRM assays are very cost effective for biomarker analysis of large studies, including clinical Phase 3 trials and can be validated for submission of results to regulatory authorities.

Caprion’s MRM assays can be performed as per GLP and can also be directly translated from animal to human samples, providing a seamless shift from pre-clinical to clinical settings supporting personalized medicine from research to practice.

Detection of low abundance proteins

In addition, Caprion has implemented an antibody-based MRM approach allowing for the detection of low abundance candidate biomarkers in biological fluids. Using antibodies coupled to magnetic beads, Caprion can enrich up to 5 markers in a single step, resulting in a highly enriched sample amenable to MRM assay. This approach shows excellent linearity and a lower limit of quantitation (LLOQ) in the 1ng/ml range.

The MRM Services deliverables include a written report which describes the details of the experimental approach, including the MRM parameters for each protein under study.


Caprion

Accreditations & Certifications

CAP accreditation and CLIA certification

CAP Accredited

Headquarters

+1 514.360.3600
+1 877.776.3443
141 President Kennedy Ave., Suite SB-5658
Montreal, Quebec
CANADA

USA

Primity Bio
48383 Fremont Blvd
Suite 118
Fremont, CA 94538
Tel.: +1 858.229.2529

Serametrix
2235 Farraday Ave,Suite N,
Carlsbad, CA, 92008, USA
Tel: +1 760 652 4060

HistoGeneX
1331 W 75th St #401,
Naperville, IL 60540, USA
Tel: +1 630-473-6655
info@histogenex.com

AUSTRALIA

Serametrix Party Limited
Suite 4/54-60 Briggs Street
Camperdown, NSW, 2050
Australia
+61 2 9168 5908

EUROPE

Caprion Biosciences Inc.
+32 (0) 71 96 23 36
8 rue Adrienne Bolland
6041 Gosselies
BELGIUM

Serametrix
Unit 22, Surrey Technology Centre,
40 Occam Road,
Guildford, Surrey, UK
GU2 7YG
Tel: +44 1483 685599

Antwerp, Belgium
HistoGeneX
Sint-Bavostraat 78
2610 Antwerpen (Wilrijk)
Belgium
Tel: +32 3 50 20 500
Sample Reception: +32 3 50 20 620
Shipments: +32 3 50 20 625

CANADA LAB

201 President Kennedy Ave., Suite PK-3900
Montreal, Quebec
CANADA
+1 514.360.3600
+1 877.776.3443



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Contact

+1 877.776.3443

info@caprion.com