Accelerating precision medicine™

Scientific Advisory Board

Caprion is proud of its industry leading scientific advisory board with world-renowned immuno-oncology experts

James E Rothman, PhD

Chairman of Arsenal Capital Partners Healthcare Advisory Board
Nobel Laureate

Dr. Rothman is the Sterling Professor of Cell Biology and Chair of the Department of Cell Biology at Yale University School of Medicine. His research discoveries have been recognized by the Nobel Prize in Physiology or Medicine in 2013, the Albert Lasker Award and the Kavli Prize for Neuroscience. Dr. Rothman has been elected to membership in the National Academy of Sciences and its Institute of Medicine. Previously, he served as Chief Scientist of General Electric Healthcare and has served on the advisory boards of Amersham PLC, Johnson & Johnson Scientific, and Merck Scientific. Dr. Rothman graduated with a B.A. from Yale College, attended Harvard Medical School and received a Ph.D. from Harvard University. He has previously been a professor at Stanford, Princeton, and Columbia Universities and at Memorial Sloan- Kettering Cancer Center, where he served as Vice Chairman of the Sloan-Kettering Institute.

Scott Gottlieb, MD

23rd Commissioner of the FDA

Dr. Gottlieb is a physician and served as the 23rd Commissioner of the U.S. Food and Drug Administration. Dr. Gottlieb’s work focuses on advancing public health through developing and implementing innovative approaches to improve medical outcomes, reshape healthcare delivery, and expand consumer choice and safety. He is currently a partner at the venture capital firm New Enterprise Associates; a resident fellow at the American Enterprise Institute; a contributor to CNBC; and a board member to Pfizer, Inc. and Illumina, Inc.

Under his leadership, the FDA advanced new frameworks for the safe and effective oversight of gene therapies, cell-based regenerative medicines, targeted drugs, digital health devices, and vaccine manufacturing. The agency implemented new reforms to standardize drug reviews and make historic improvements of post-market data collection and the use of real-world evidence. He promoted policies to reduce death and disease from tobacco, improve food innovation and safety, and aggressively confront addiction crises. The agency’s historic and prolific advances in new policy distinguished his tenure as the FDA’s commissioner, in addition to a record-setting number of approvals of novel drugs, medical devices, and generic medicines.

Previously, Dr. Gottlieb served as the FDA’s Deputy Commissioner for Medical and Scientific Affairs and before that, as a Senior Adviser to the Administrator of the Centers for Medicare and Medicaid Services, where he helped advance policies to improve healthcare quality and promote the effective use of new medical technologies. Dr. Gottlieb was a practicing hospitalist and a Clinical Assistant Professor at the New York University School of Medicine. He is an elected member of the National Academy of Medicine.

Garry Nolan, PhD

Department of Microbiology and Immunology, Stanford University

Dr. Nolan is the Rachford and Carlota A. Harris Professor in the Department of Microbiology and Immunology at Stanford University School of Medicine. He trained with Leonard Herzenberg (for his PhD) and Nobelist Dr. David Baltimore (for postdoctoral work on the first cloning/characterization of NF-κB p65/RelA and the development of 293T rapid retroviral production systems). He has published over 200 research papers, holds 17 US patents and has been honored as one of the top 25 inventors at Stanford University. He has trained more than 30 graduate students and 40 postdoctoral or clinical fellows. Dr. Nolan’s areas of research include hematopoiesis, cancer and leukemia, autoimmunity and inflammation, and computational approaches for network and systems immunology. His most recent efforts are focused on a single cell analysis advance using a mass spectrometry-flow cytometry hybrid device, called CyTOF. The approach uses an advanced ion plasma source to determine the levels of tagged reagents bound to cells—enabling a vast increase in the number of parameters that can be measured per cell. Another recent innovation is termed molecular ion beam imaging (MIBI), a system that also uses mass tags that will enable sub-light imaging (5 nm resolution) of tissue sections with 50 or more parameters per image. His laboratory has already begun a large-scale mapping of the hematopoietic hierarchy in healthy human bone marrow at an unprecedented level of detail. A large focus of his lab is the development and utilization of machine learning algorithms to interpret the large high-dimensional datasets being produced by CyTOF and MIBI. Dr. Nolan’s efforts are to enable a deeper understanding not only of normal immune function, trauma, and other inflammatory events but also detailed substructures of leukemias and solid cancers—which will enable wholly new understandings, permitting better management of disease and clinical outcomes.

Rafick-Pierre Sékaly, PhD

Department of Pathology, Case Western Reserve University

Dr. Sekaly is the Richard J. Fasenmyer Professor of Immunopathogenesis at the Case Western Reserve University School of Medicine, Director of the Center for Systems Immunology, and member of the Hematopoietic and Immune Cancer Biology Program at the Case Western Comprehensive Cancer Center. Dr. Sekaly’s lab has been focused for the past 20 years on developing a better understanding of the human immune response to vaccines and to chronic viral infections, with a specific focus on cancer and HIV infection. Over the past 7 years, Dr. Sekaly and his team have implemented the use of system biology approaches to monitor the diversity of memory T cells and to identify the mechanisms underlying it. His group has also pioneered the application of systems biology approaches to the understanding of mechanisms of action of the licensed vaccines and adjuvants, and has shown for the first time the diversity of the mechanism that lead to the establishment and persistence of different memory T cell subsets. Dr. Sekaly’s work has led to more than 342 peer-reviewed articles in scientific journals and more than 23 patents. He has been a principal investigator on numerous grants from the National Institutes of Health and foundations, including the Bill and Melinda Gates Foundation and the American Foundation for AIDS Research.

George D. Demetri, MD, FASCO

Senior Vice President for Experimental Therapeutics and Director, Sarcoma Center,
Dana-Farber Cancer Institute; Professor and Co-Director, Ludwig Center at Harvard

George Demetri, MD, FASCO has dedicated his career to translational research aimed at understanding and treating precisely-defined subsets of cancers. He was a pioneer in the development of imatinib (Gleevec®), the first cancer therapy targeting gastrointestinal stromal tumor (GIST) as a molecularly defined subset of sarcoma. Subsequently, his work has contributed to the U.S. FDA and worldwide regulatory approvals of several other “smart drugs” for cancer, including sunitinib (Sutent®) and regorafenib (Stivarga®) for GIST, tazemetostat (Tazverik®) for epithelioid sarcomas, as well as pazopanib (Votrient®) and trabectedin (Yondelis®) for other sarcomas. In a related contribution, Dr. Demetri served on the Scientific Advisory Board for Plexxikon to help develop the first mutant BRAF inhibitor, vemurafenib (Zelboraf®), a mutation-targeted therapy for a subset of melanomas. Most recently, he helped starting Blueprint Medicines in Cambridge, MA, which recently announced the U.S. FDA approval of avapritinib (Ayvakit®) for a mutationally-defined subset of GIST.

He received his undergraduate degree in Biochemistry from Harvard College, then was a research fellow at the Universite of Besancon, France before receiving his medical degree from Stanford University School of Medicine. Subsequently, he completed his residency and became Chief Residency in Internal Medicine at the University of Washington Medical Center in Seattle before training as a fellow in Medical Oncology at the Dana-Farber Cancer Institute and Harvard Medical School, where he has served as an Attending Physician since 1989.

Dr. Demetri is a Professor of Medicine at the Harvard Medical School (HMS), where he is co-Director of the Ludwig Center at Harvard and a co-director of the HMS post-graduate course entitled “High Impact Cancer Research: Cancer Biology and Therapeutics”. He also teaches a Harvard College Freshman Seminar on the Scientific, Ethical and Humanistic Aspects of Cancer. He has served on the Board of Directors of the American Association for Cancer Research (AACR) and now chairs the AACR Science Policy and Government Affairs Committee. Dr. Demetri was a founding director of the annual AACR special workshop on Translational Cancer Research for the Basic Scientist. He also serves as a member of the Board of Directors for Blueprint Medicines and Translate Bio, both in Cambridge Massachusetts.

Thomas Powles, MD

Professor of Genitourinary Oncology, Barts Cancer Institute

Dr. Powles is a Clinical Professor of Genitourinary Oncology and the lead for solid tumor research at Barts Cancer Institute in the United Kingdom. His work focuses on a spectrum of clinical studies from Phase I to randomized Phase III, with the majority of the studies being translational Phase II investigating novel targeted and immune therapies. Alongside these trials, Dr. Powles’ research focuses on correlation of novel biomarkers and aims to define markers that are of prognostic value and can predict response or resistance to therapy. Dr. Powles has written in over 100 peer review papers in this area and has received grant income from national and international funding bodies. He graduated from St. Bartholomew’s Medical School, London in 1996, and completed his post-graduate training in oncology in 2005, receiving an MD from the University of London in 2006.

Charles Sawyers, MD

Investigator, Howard Hughes Medical Institute; Marie-Josée and Henry Kravis Chair in Human Oncology and Pathogenesis; Chairman, Human Oncology and Pathogenesis Program

Charles L. Sawyers received a BA from Princeton University in 1981 and an MD from Johns Hopkins University School of Medicine in 1985, and completed his internal medicine residency at UCSF. He became a Howard Hughes Medical Institute Investigator in 2002 while at UCLA, and then moved to the Memorial Sloan Kettering Cancer Center in 2006 where he currently serves as the Chair of the Human Oncology and Pathogenesis Program.

Sawyers studies mechanisms of cancer drug resistance with an eye toward developing novel therapies. He co-discovered the antiandrogen drug enzalutamide (Xtandi®) that was approved by the FDA in 2012 for treatment of advanced prostate cancer. He shared the 2009 Lasker-DeBakey Clinical Medical Research Award for the development of the ABL kinase inhibitor imatinib for patients with chronic myeloid leukemia and the second generation ABL inhibitor dasatinib to overcome imatinib resistance. He received the 2013 Breakthrough Prize in Life Sciences, the 2013 Taubman Prize for Excellence in Translational Medical Science and the 2015 BBVA Knowledge Award in Biomedicine.

Sawyers is a member of the National Academy of Sciences, the National Academy of Medicine (formerly IOM) and the American Academy of Arts and Sciences. He is past President of the American Association for Cancer Research (AACR) and the American Society of Clinical Investigation (ASCI), was appointed to the National Cancer Advisory Board by President Obama and has served on the Board of Directors of Novartis since 2013. He also serves as Steering Committee Chair of the AACR Project GENIE, an international consortium of cancer centers who share genomic and clinical data from patients treated at their respective clinical sites.

Jedd D. Wolchok, MD, PhD, FASCO

Chief, Immuno-Oncology Service, Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center

Jedd Wolchok is Chief of the Immuno-Oncology Service and holds The Lloyd J. Old Chair in Clinical Investigation at Memorial Sloan Kettering Cancer Center, Associate Director of the Ludwig Center for Cancer Immunotherapy and Director of the Parker Institute for Cancer Immunotherapy at MSK. Dr. Wolchok is a clinician-scientist exploring innovative immunotherapeutic strategies in laboratory models, and a principal investigator in numerous pivotal clinical trials. He specializes in the treatment of melanoma. The focus of his translational research laboratory is to investigate innovative means to modulate the immune response to cancer as well as to better understand the mechanistic basis for sensitivity and resistance to currently available immunotherapies.

Carl June, MD

Director of the Center for Cellular Immunotherapies, University of Pennsylvania

Carl June is the Richard W. Vague Professor in Immunotherapy in the Department of Pathology and Laboratory Medicine. He is currently Director of the Center for Cellular Immunotherapies at the Perelman School of Medicine, and Director of the Parker Institute for Cancer Immunotherapy at the University of Pennsylvania. He is a graduate of the Naval Academy in Annapolis, and Baylor College of Medicine in Houston, 1979. He received his graduate training in immunology and malaria with Dr. Paul-Henri Lambert at the World Health Organization, Geneva, Switzerland from 1978-79, and his post-doctoral training in transplantation biology with E. Donnell Thomas and John Hansen at the Fred Hutchinson Cancer Research Center in Seattle from 1983 - 1986. He is board certified in Internal Medicine and Medical Oncology. He maintains a research laboratory that studies various mechanisms of lymphocyte activation that relate to immune tolerance and adoptive immunotherapy for cancer and chronic infection. In 2011, his research team published findings detailing a new therapy in which patients with refractory and relapsed chronic lymphocytic leukemia were treated with genetically engineered versions of their own T cells. The treatment has now been used with promising results to treat children with refractory acute lymphoblastic leukemia. He has published more than 350 manuscripts and is the recipient of numerous prizes and honors, including election to the Institute of Medicine in 2012 and the American Academy of Arts and Sciences in 2014, the William B Coley award, the Richard V Smalley Memorial Award from the Society for Immunotherapy of Cancer, the AACR-CRI Lloyd J. Old Award in Cancer Immunology, the Philadelphia Award in 2012, the Taubman Prize for Excellence in Translational Medical Science in 2014 (shared w S. Grupp, B. Levine, D. Porter), the Paul Ehrlich and Ludwig Darmstaedter Prize (shared w J. Allison), the Novartis Prize in Immunology (shared w Z. Eshaar and S. Rosenberg), the Karl Landsteiner Memorial award, the Debrecen Award and a lifetime achievement award from the Leukemia and Lymphoma Society.



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