Caprion

Finding proteins that hit the mark

ProteoCarta Technology Overview

Successful proteomic studies require careful study design, sample preparation, study execution, and data analysis to identify biologically and clinically relevant proteins. Caprion has over a decade of experience collaborating with pharmaceutical, biotech, and non-for-profit organizations to design and execute proteomics studies to meet customer needs by combining our expertise in three key areas:

 

Sample Preparation

Fractionation or enrichment improves assay sensitivity and maximizes the opportunities to discover novel, biologically-relevant biomarkers. Strategies routinely utilized at Caprion include:

  • Depletion of high abundance proteins
  • Chromatographic fractionation
  • Subcellular fractionation
  • Enrichment of membrane proteins, secretory proteins, or phosphoproteins
  • Isolation of exosomes or specific organelles

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Mass Spectrometry

Multiple MS technologies to support both unbiased and targeted proteomics studies for discovery through to assay deployment for regulated environments

  • LC-MS/MS for unbiased discovery of novel biomarkers and drug targets
  • MRM mass spectrometry for biomarker screening, verification, and fit-for-purpose assays
  • Robust processes for high quality, reproducible results
  • Can be adapted for analysis of specific post-translational modifications

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Bioinformatics and Biostatistics

Caprion’s multidisciplinary bioinformatics team is an integral part of every project, from study design and quality control through to statistical analysis and biological interpretation of results. Caprion’s PhD-level bioinformatics team has experience with:

  • Optimization of study design to avoid common pitfalls
  • Identification of outliers and pre-analytical biases
  • Selection of statistical tests to match the study design and goals
  • Extensive data interpretation, including pathway analysis and literature assessment

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