Caprion

Accelerating precision medicine™

Myeloid-Derived Suppressor Cells (MDSC) Assays

Predict immune response to checkpoint inhibitors and improve your patient stratification and selection by monitoring MDSC

Developed by

Insight into the cellular response to your checkpoint inhibitor

MDSC – A potential biomarker to predict the outcome of checkpoint inhibitors and support personalize medicine

The treatment of cancer has been revolutionized by the development of immunotherapies including PD-1 / PD-L1 inhibitors and other checkpoint blockades. However, response rates were variable and better response rates were seen in patients with lower levels of MDSC. Patients with elevated MDSC may benefit from supplemental drugs and many combination therapies are currently in clinical development. Some of these combinations are thought to work by inhibiting MDSC and thereby creating a permissive environment for activated T cells.

ASSAYS TO HELP YOU MONITOR MDSC AT EVERY STEP

For your exploratory assay to monitor immune responses

A biomarker to monitor checkpoint inhibitors effectiveness

A biomarker to select and stratify your patient population during trials

Accelerate your drug development with validated assays

Flow cytometry provides an unrivalled view of the cellular immune response to cancer, measuring important peripheral immune cells. Caprion’s MDSC assays will help you better predict treatment outcome and are available for exploratory research as well as clinical CLIA studies.


  • Flow panels designed specifically to measure the frequency of blood monocytic and/or granulocytic MDSC
  • Assays can be performed using BD Trucount™ tubes for absolute cell counts
  • Data analysis performed using icScore™, a proprietary algorithm to support non-biased reliable gating for HLA-DR data analysis, licensed from Memorial Sloan Kettering Cancer Center
  • Option to use the CLIA-certified assay to investigate mMDSC

Move your research forward with confidence

  • Quality sample handling with stabilizing MDSC Cyto-Chex® BCT
  • Specific flow panels for monocytic/granulocytic MDSC
  • icScore™ data analysis for comprehensive and reliable analysis and interpretation
  • CLIA-certified option

Our MDSC assays were proven effective in major studies:

  • Wan D et al. Sequential depletion of myeloid-derived suppressor cells and tumor cells with a dual-pH-sensitive conjugated micelle system for cancer chemoimmunotherapy. J Control Release 2020;317:43-56. Full text
  • Callahan MK et al. Nivolumab plus ipilimumab in patients with advanced melanoma: updated survival, response, and safety data in a phase I dose-escalation study. J Clin Oncol 2018;36(4):391-398. Full text
  • De Henau O et al. Overcoming resistance to checkpoint blockade therapy by targeting PI3Kγ in myeloid cells. Nature 2016;539:443-447. Full text
  • Kitano S et al. Computational algorithm-driven evaluation of monocytic myeloid-derived suppressor cell frequency for prediction of clinical outcomes. Cancer Immunol Res 2014;2(8):812–21. Full text
  • Wolchok JD et al. Nivolumab plus ipilimumab in advanced melanoma. NEJM 2013;369(2):122-33. Full text

 


Caprion

Accreditations & Certifications

CAP accreditation and CLIA certification

CAP Accredited

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+1 514.360.3600
+1 877.776.3443
141 President Kennedy Ave., Suite SB-5658
Montreal, Quebec
CANADA

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201 President Kennedy Ave., Suite PK-3900
Montreal, Quebec
CANADA
+1 514.360.3600
+1 877.776.3443



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info@caprion.com