Caprion

Accelerating precision medicine™

CNS ProteoCarta™

Human Cerebrospinal Fluid (CSF) MRM Panel for CNS Diseases

the biomarker consortiumWorking in conjunction with the Biomarker Consortium as the selected discovery partner, Caprion has developed CNS ProteoCarta™, an easily customizable and highly multiplexed mass spectrometry based assay, useful in monitoring central nervous system (CNS) proteins associated with neurological disorders such as Alzheimer’s Disease and Parkinson’s Disease.

CNS ProteoCarta allows detection and quantification of 142 proteins in human cerebral spinal fluid (CSF) in a single multiplexed Multiple Reaction Monitoring (MRM) assay, requiring only 75 ul of CSF of this often difficult-to-obtain specimen.

CNS ProteoCarta™ Advantages:

  • Highly Multiplexed (142 Proteins)
  • Developed Specifically for CSF
  • Easily & Rapidly Expandable
    – Add new proteins in 8 to 12 weeks
  • Small Sample Volumes (75 uL/sample)
  • No antibodies required
  • Exceptional molecular specificity
  • Sensitive
ProteoCarta CSF Assay Specifications

To learn more about our CNS ProteoCarta Panel and how MRM assay provides significant advantages over other standard quantification methods, please refer our CNS ProteoCarta brochure or contact us directly.


   CNS ProteoCarta brochure

 

CNS ProteoCarta is a proud grant recipient of The Michael J. Fox Foundation for identifying Parkinson's Disease biomarkers. To learn more about our grant, click here.

CNS ProteoCarta Detected Proteins

No. UniProt_ID Gene Protein Description
1. A1BG_HUMAN A1BG Alpha-1B-glycoprotein precursor
2. AFAM_HUMAN AFM Afamin precursor
3. FETUA_HUMAN AHSG Alpha-2-HS-glycoprotein precursor
4. ALDOA_HUMAN ALDOA Fructose-bisphosphate aldolase A
5. AMBP_HUMAN AMBP Protein AMBP precursor
6. APLP2_HUMAN APLP2 Amyloid-like protein 2 precursor
7. APOB_HUMAN APOB Apolipoprotein B-100 precursor
8. APOD_HUMAN APOD Apolipoprotein D precursor
9. APOE_HUMAN APOE Apolipoprotein E precursor
10. A4_HUMAN APP Amyloid beta A4 protein precursor
11. B2MG_HUMAN B2M Beta-2-microglobulin precursor
12. B3GN1_HUMAN B3GNT1 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase
13. BACE1_HUMAN BACE1 Beta-secretase 1 precursor
14. BASP1_HUMAN BASP1 Brain acid soluble protein 1
15. BTD_HUMAN BTD Biotinidase precursor
16. C1QB_HUMAN C1QB Complement C1q subcomponent subunit B precursor
17. CO2_HUMAN C2 Complement C2 precursor
18. CO3_HUMAN C3 Complement C3 precursor
19. CO4A_HUMAN C4A Complement C4-A precursor
20. CO5_HUMAN C5 Complement C5 precursor
21. CO6_HUMAN C6 Complement component C6 precursor
22. CO8B_HUMAN C8B Complement component C8 beta chain precursor
23. CAH1_HUMAN CA1 Carbonic anhydrase 1
24. CA2D1_HUMAN CACNA2D1 Voltage-dependent calcium channel subunit alpha-2/delta-1 precursor
25. CADM3_HUMAN CADM3 Cell adhesion molecule 3 precursor
26. CATA_HUMAN CAT Catalase
27. CCKN_HUMAN CCK Cholecystokinin precursor
28. CD14_HUMAN CD14 Monocyte differentiation antigen CD14 precursor
29. CD59_HUMAN CD59 CD59 glycoprotein precursor
30. CAD13_HUMAN CDH13 Cadherin-13 precursor
31. CFAB_HUMAN CFB Complement factor B precursor
32. CMGA_HUMAN CHGA Chromogranin-A precursor
33. SCG1_HUMAN CHGB Secretogranin-1 precursor
34. CH3L1_HUMAN CHI3L1 Chitinase-3-like protein 1 precursor
35. CSTN1_HUMAN CLSTN1 Calsyntenin-1 precursor
36. CSTN3_HUMAN CLSTN3 Calsyntenin-3 precursor
37. CLUS_HUMAN CLU Clusterin precursor
38. CNDP1_HUMAN CNDP1 Beta-Ala-His dipeptidase precursor
39. CNTN1_HUMAN CNTN1 Contactin-1 precursor
40. CNTN2_HUMAN CNTN2 Contactin-2 precursor
41. CNTP2_HUMAN CNTNAP2 Contactin-associated protein-like 2 precursor
42. COCH_HUMAN COCH Cochlin precursor
43. CERU_HUMAN CP Ceruloplasmin precursor
44. CRP_HUMAN CRP C-reactive protein precursor
45. CYTC_HUMAN CST3 Cystatin-C precursor
46. DIAC_HUMAN CTBS Di-N-acetylchitobiase precursor
47. CATD_HUMAN CTSD Cathepsin D precursor
48. CATL1_HUMAN CTSL Cathepsin L1 precursor
49. CUTA_HUMAN CUTA Protein CutA precursor
50. DAG1_HUMAN DAG1 Dystroglycan precursor
51. FBLN3_HUMAN EFEMP1 EGF-containing fibulin-like extracellular matrix protein 1 precursor
52. ENOG_HUMAN ENO2 Gamma-enolase
53. ENPP2_HUMAN ENPP2 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 precursor
54. EXTL2_HUMAN EXTL2 Exostosin-like 2
55. THRB_HUMAN F2 Prothrombin precursor
56. FABPH_HUMAN FABP3 Fatty acid-binding protein, heart
57. FAM3C_HUMAN FAM3C Protein FAM3C precursor
58. FBLN1_HUMAN FBLN1 Fibulin-1 precursor
59. FMOD_HUMAN FMOD Fibromodulin precursor
60. VTDB_HUMAN GC Vitamin D-binding protein precursor
61. GFAP_HUMAN GFAP Glial fibrillary acidic protein
62. GOLM1_HUMAN GOLM1 Golgi membrane protein 1
63. AATC_HUMAN GOT1 Aspartate aminotransferase, cytoplasmic
64. AATM_HUMAN GOT2 Aspartate aminotransferase, mitochondrial precursor
65. GRIA4_HUMAN GRIA4 Glutamate receptor 4 precursor
66. HBA_HUMAN HBA1 Hemoglobin subunit alpha
67. HBB_HUMAN HBB Hemoglobin subunit beta
68. HEMO_HUMAN HPX Hemopexin precursor
69. IBP2_HUMAN IGFBP2 Insulin-like growth factor-binding protein 2 precursor
70. IGSF8_HUMAN IGSF8 Immunoglobulin superfamily member 8 precursor
71. I18BP_HUMAN IL18BP Interleukin-18-binding protein precursor
72. ITIH1_HUMAN ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1 precursor
73. ITIH5_HUMAN ITIH5 Inter-alpha-trypsin inhibitor heavy chain H5 precursor
74. KLK10_HUMAN KLK10 Kallikrein-10 precursor
75. KLK11_HUMAN KLK11 Kallikrein-11 precursor
76. KLK6_HUMAN KLK6 Kallikrein-6 precursor
77. KNG1_HUMAN KNG1 Kininogen-1 precursor
78. L1CAM_HUMAN L1CAM Neural cell adhesion molecule L1 precursor
79. LAMB2_HUMAN LAMB2 Laminin subunit beta-2 precursor
80. LPHN1_HUMAN LPHN1 Latrophilin-1 precursor
81. A2GL_HUMAN LRG1 Leucine-rich alpha-2-glycoprotein precursor
82. LRC4B_HUMAN LRRC4B Leucine-rich repeat-containing protein 4B precursor
83. LTBP2_HUMAN LTBP2 Latent-transforming growth factor beta-binding protein 2 precursor
84. MUC18_HUMAN MCAM Cell surface glycoprotein MUC18 precursor
85. TRFM_HUMAN MFI2 Melanotransferrin precursor
86. MOG_HUMAN MOG Myelin-oligodendrocyte glycoprotein precursor
87. NBL1_HUMAN NBL1 Neuroblastoma suppressor of tumorigenicity 1 precursor
88. NCAM1_HUMAN NCAM1 Neural cell adhesion molecule 1 precursor
89. NCAM2_HUMAN NCAM2 Neural cell adhesion molecule 2 precursor
90. NCAN_HUMAN NCAN Neurocan core protein precursor
91. NICA_HUMAN NCSTN Nicastrin precursor
92. NEGR1_HUMAN NEGR1 Neuronal growth regulator 1 precursor
93. NELL2_HUMAN NELL2 Protein kinase C-binding protein NELL2 precursor
94. NEO1_HUMAN NEO1 Neogenin precursor
95. NGF_HUMAN NGF Beta-nerve growth factor precursor
96. NPTX1_HUMAN NPTX1 Neuronal pentraxin-1 precursor
97. NPTX2_HUMAN NPTX2 Neuronal pentraxin-2 precursor
98. NPTXR_HUMAN NPTXR Neuronal pentraxin receptor
99. NRCAM_HUMAN NRCAM Neuronal cell adhesion molecule precursor
100. NRX1A_HUMAN NRXN1 Neurexin-1 precursor
101. NRX2A_HUMAN NRXN2 Neurexin-2 precursor
102. NRX3A_HUMAN NRXN3 Neurexin-3 precursor
103. MIME_HUMAN OGN Mimecan precursor
104. AMD_HUMAN PAM Peptidyl-glycine alpha-amidating monooxygenase precursor
105. PPN_HUMAN PAPLN Papilin precursor
106. PIMT_HUMAN PCMT1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase
107. PCSK1_HUMAN PCSK1N ProSAAS precursor
108. PDYN_HUMAN PDYN Proenkephalin-B precursor
109. PGRP2_HUMAN PGLYRP2 N-acetylmuramoyl-L-alanine amidase precursor
110. KPYM_HUMAN PKM Pyruvate kinase PKM
111. PLMN_HUMAN PLG Plasminogen precursor
112. PLDX1_HUMAN PLXDC1 Plexin domain-containing protein 1 precursor
113. PRDX1_HUMAN PRDX1 Peroxiredoxin-1
114. PRDX2_HUMAN PRDX2 Peroxiredoxin-2
115. PRDX3_HUMAN PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial precursor
116. PRDX6_HUMAN PRDX6 Peroxiredoxin-6
117. PTGDS_HUMAN PTGDS Prostaglandin-H2 D-isomerase precursor
118. PTPRN_HUMAN PTPRN Receptor-type tyrosine-protein phosphatase-like N precursor
119. PVRL1_HUMAN PVRL1 Poliovirus receptor-related protein 1 precursor
120. SCG2_HUMAN SCG2 Secretogranin-2 precursor
121. SCG3_HUMAN SCG3 Secretogranin-3 precursor
122. A1AT_HUMAN SERPINA1 Alpha-1-antitrypsin precursor
123. AACT_HUMAN SERPINA3 Alpha-1-antichymotrypsin precursor
124. KAIN_HUMAN SERPINA4 Kallistatin precursor
125. PEDF_HUMAN SERPINF1 Pigment epithelium-derived factor precursor
126. NEUS_HUMAN SERPINI1 Neuroserpin precursor
127. SE6L1_HUMAN SEZ6L Seizure 6-like protein precursor
128. SIAE_HUMAN SIAE Sialate O-acetylesterase precursor
129. SLIK1_HUMAN SLITRK1 SLIT and NTRK-like protein 1 precursor
130. SODC_HUMAN SOD1 Superoxide dismutase [Cu-Zn]
131. SODE_HUMAN SOD3 Extracellular superoxide dismutase [Cu-Zn] precursor
132. SORC1_HUMAN SORCS1 VPS10 domain-containing receptor SorCS1 precursor
133. SPRL1_HUMAN SPARCL1 SPARC-like protein 1 precursor
134. SPON1_HUMAN SPON1 Spondin-1 precursor
135. OSTP_HUMAN SPP1 Osteopontin precursor
136. TGFB1_HUMAN TGFB1 Transforming growth factor beta-1 precursor
137. TIMP1_HUMAN TIMP1 Metalloproteinase inhibitor 1 precursor
138. TNR21_HUMAN TNFRSF21 Tumor necrosis factor receptor superfamily member 21 precursor
139. TTHY_HUMAN TTR Transthyretin precursor
140. UBB_HUMAN UBB Polyubiquitin-B precursor
141. VASN_HUMAN VASN Vasorin precursor
142. VGF_HUMAN VGF Neurosecretory protein VGF precursor