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Press Release

Caprion Pharmaceuticals acquires therapeutic antibody clinical program and antibody technologies from Sunol Molecular

MONTREAL, Canada, June 7, 2004 - Caprion Pharmaceuticals announced today the acquisition of therapeutic antibodies currently in Phase I clinical trials for the treatment of Hemolytic Uremic Syndrome (HUS) resulting from E. coli infection, as well as technologies for the generation and production of humanized monoclonal antibodies.

"This acquisition of both a clinical program and proprietary compound development technologies represents an important transition for us toward becoming a more fully integrated biopharmaceutical company while adding to our ability to drive value off of our distinctive CellCartaTM discovery platform," said Lloyd M. Segal, Caprion's President & CEO. "Moreover, we are excited about the potential of the HUS program in that it addresses a significant, un-served market."

Annually, more than 200,000 people are affected by E. coli-related disease, with approximately 91,000 of those occurring in the US. There is currently no effective treatment to prevent the life threatening complications that can result from pathogenic E. coli infection. E. coli toxins cause tissue damage leading to HUS, kidney failure and severe brain damage, especially in children and the elderly.

"As the HUS program prepared to enter Phase II clinical trials under the direction of a division of the National Institutes of Health (NIH), we wanted to ensure that it received the focus, resources and attention required for the program's success," commented Dr. Hing Wong, Sunol's CEO. "We have found a partner that is well positioned financially and has the expertise to drive this program. This collaboration will also allow Sunol to focus on its core areas of interest, cardiovascular and inflammatory diseases."

Caprion will apply the antibody technologies to the development of its pipeline of proprietary tumor antigen targets discovered using CellCarta, its proteomic profiling platform technology. Initially, the focus of this development will be on the generation of antibody therapeutics for the treatment of solid tumors.

This transaction is subject to the approval of Caprion shareholders.


About Caprion Pharmaceuticals
Caprion is a leading proteomics-based drug discovery company applying CellCarta® to discover and develop innovative products for the diagnosis and treatment of disease. Caprion has established target discovery partnerships with Abbott Laboratories (NYSE: ABT) in lung cancer, and Biogen IDEC (NASDAQ: BIIB) in colon cancer, and pharmaco-proteomic and biomarker discovery collaborations with Wyeth (NYSE: WYE), AstraZeneca (NYSE: AZN) and Merck and Co (NYSE: MRK). Caprion has also partnered products for Mad Cow Disease and variant Creutzfeldt-Jacob Disease diagnostics, in development with IDEXX Laboratories (NASDAQ: IDXX) and Ortho-Clinical Diagnostics, a Johnson & Johnson company (NYSE:JNJ). For more on Caprion, see

About Sunol Molecular
Sunol Molecular Corp. began operations in 1996 and is a privately held company engaged in the discovery and development of novel human therapeutics to treat cardiovascular disease, cancer, inflammatory disorders and infectious diseases. Sunol currently has multiple products in various stages of clinical development. Sunol Molecular Corp is located in Miramar, FL. For more information on Sunol please visit their web site at


Caprion Pharmaceuticals
Katherine Bonter
(514) 228-3624
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Emily Poe
Euro RSCG Life NRP
(212) 845-4266

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